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Index > Protein center > Spag9(Gene name) > Mouse
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  • Spag9 (Gene name),
  • C-Jun-amino-terminal kinase-interacting protein 4 (Protein name ),  JIP4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Spag9(Jip4;Jsap2;Kiaa0516;Mapk8ip4);
    Protein name:
    C-Jun-amino-terminal kinase-interacting protein 4(JIP-4;JNK-interacting protein 4);
    Alternative:
    JNK/SAPK-associated protein 2(JSAP2);JNK-associated leucine-zipper protein(JLP);Sperm-associated antigen 9;Mitogen-activated protein kinase 8-interacting protein 4;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homooligomer. Interacts with MAX, MAPK8, MAPK14, MAPK10, MAPK14, MAP3K3, MYC, KNS2, and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8.
    Function:
    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module.
    Subcellular Location:
    Cytoplasm Cytoplasm perinuclear region Perinuclear distribution in response to stress signals such as UV radiation.
    Protein Attributes:
    Sequence length:
    1321
    Sequence:
    50:
    MELEDGVVYQ | EEPGGSGAVM | SERVSGLAGS | IYREFERLIG | RYDEEVVKEL | 
    100:
    MPLVVAVLEN | LDSVFAQDQE | HQVELELLRD | DNEQLITQYE | REKALRKHAE | 
    150:
    EKFIEFEDSQ | EQEKKDLQTR | VESLESQTRQ | LELKAKNYAD | QISRLEEREA | 
    200:
    ELKKEYNALH | QRHTEMIHNY | MEHLERTKLH | QLSGSDQLEA | TAHSRIRKER | 
    250:
    PISLGIFPLP | AGDGLLTPDT | QKGGETPGSE | QWKFQELSQP | RSHTSLKVSH | 
    300:
    SPEPPKAVEQ | EDELSDISQG | GSKATTPAST | ANSDVSAIPP | DTPSKEDNEG | 
    350:
    FVKGTDTSNK | SEISKHIEVQ | VAQETRNVST | ESGENEEKSE | VQAIIESTPE | 
    400:
    LDMDKDLSGY | KGSSTPTKGI | ENKAFDRNTE | SLFEELSSAG | SGLIGDVDEG | 
    450:
    ADLLGMGREV | ENLILENTQL | LETKNALNVV | KNDLIAKVDE | LTCEKDVLQG | 
    500:
    ELEAVKQAKL | KLEDKNRELE | EELRKARAEA | EDARQKAKDD | DDSDIPTAQR | 
    550:
    KRFTRVEMAR | VLMERNQYKE | RLMELQEAVR | WTEMIRASRE | NPAMQEKKRS | 
    600:
    SIWQFFSRLF | SSSSNATKKP | EPPVNLKYNA | PTSHVTPSVK | KRSSTLSQLP | 
    650:
    GDKSKAFDFL | SEETEASLAS | RREQKREQYR | QVKAHVQKED | GRVQAFGWSL | 
    700:
    PQKYKQVANG | QGETKMKNLP | VPVYLRPLDE | KDASMKLWCA | VGVNLSGGKT | 
    750:
    RDGGSVVGAS | VFYKDIAGLD | TEGSKQRSAS | QSSLDKLDQE | LKEQQKEFKN | 
    800:
    QEELSSQVWI | CTSTHSTTKV | IIIDAVQPGN | ILDSFTVCNS | HVLCIASVPG | 
    850:
    ARETDYPAGE | ELSESGQVDK | ASLCGSMTSN | SSAEMDSLLG | GITVVGCSTE | 
    900:
    GLTGAATSPS | TNGASPVIEK | PPEMETENSE | VDENIPTAEE | ATEATEGNAG | 
    950:
    STEDTVDISQ | PGVYTEHVFT | DPLGVQIPED | LSPVFQSSND | SDVYKDQISV | 
    1000:
    LPNEQDLARE | EAQKMSSLLP | TMWLGAQNGC | LYVHSSVAQW | RKCLHSIKLK | 
    1050:
    DSILSIVHVK | GIVLVALADG | TLAIFHRGVD | GQWDLSNYHL | LDLGRPHHSI | 
    1100:
    RCMTVVHDKV | WCGYRNKIYV | VQPKAMKIEK | SFDAHPRKES | QVRQLAWVGD | 
    1150:
    GVWVSIRLDS | TLRLYHAHTY | QHLQDVDIEP | YVSKMLGTGK | LGFSFVRITA | 
    1200:
    LMVSCNRLWV | GTGNGVIISI | PLTETNKTSG | TPGNRPGSVI | RVYGDENSDK | 
    1250:
    VTPGTFIPYC | SMAHAQLCFH | GHRDAVKFFV | AVPGQVISPQ | SSSGGADLTA | 
    1300:
    DKAGSSAQEP | SSQTPLKSML | VISGGEGYID | FRMGDEGGES | ELLGEDLPLE | 
    1321:
    PSVTKAERSH | LIVWQVMCGN | E
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse JIP-4
    Cat.:
    E12202m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse JIP-4
    Cat.:
    E12202h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Mouse JIP-4
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse JIP-4
    Cat.:
    U12202m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse JIP-4
    Polyclonal Antibody for Mouse JIP-4
    Cat.:
    P12202Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse JIP-4
    Monoclonal Antibody for Mouse JIP-4
    Protein for Mouse JIP-4
    Protein for Mouse JIP-4

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors."
      Lee C.M. , Onesime D. , Reddy C.D. , Dhanasekaran N. , Reddy E.P.
      Proc. Natl. Acad. Sci. U.S.A.99:14189-14194(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH MAX; MAPK8; MAPK14; MAP3K3; MYC AND MAP2K4;SUBCELLULAR LOCATION
    2. 2.
      "Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways."
      Kelkar N. , Standen C.L. , Davis R.J.
      Mol. Cell. Biol.25:2733-2743(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6);FUNCTION;INTERACTION WITH KNS2 AND MAPK8;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION
      strain: C57BL/6J.
      tissue: Testis.
    3. 3.
      "JSAP2, a novel member of the JSAP1 JNK scaffold protein family."
      Takamatsu N. , Tochigi M. , Ito M. , Odama Y. , Xu P. , Nakabeppu Y. , Yoshioka K. , Shiba T.
      Submitted (2000-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Testis.
    4. 4.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Seino S. , Nishimura M. , Kaisho T. , Hoshino K. , Kitamura H. , Nagase T. , Ohara O. , Koga H.
      DNA Res.11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Brain.
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      strain: C57BL/6J.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];ALTERNATIVE SPLICING
      strain: C57BL/6J.
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
      strain: C57BL/6.
      tissue: Brain.
      tissue: Olfactory epithelium.
    8. 8.
      "JLP associates with kinesin light chain 1 through a novel leucine zipper-like domain."
      Nguyen Q. , Lee C.M. , Le A. , Reddy E.P.
      J. Biol. Chem.280:30185-30191(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KNS2;INDUCTION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-733;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    10. 10.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-217 AND THR-365;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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